News 2017

December 2017

Tina's work on the potential utility of stored umbilical cord blood as a source of cells for immunotherapy is featured on the McMaster Faculty of Health Sciences News page. Click here to read more.


Nicole and Isabella's paper on the benefits of high intensity interval training is published in Cancer Prevention:

High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women.

Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, Gibala MJ, Ashkar AA.

J Cancer Prev. 2017 Dec;22(4):260-266. doi: 10.15430/JCP.2017.22.4.260. Epub 2017 Dec 30.

PMID:29302585

November 2017

 Tina's work demonstrating the potential of stored umbilical cord blood for use as an immunotherapy against breast cancer is published in Journal Immunotherapy: 

Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood are Cytotoxic Against Primary Breast Cancer Cells.

Nham T, Poznanski SM, Fan IY, Vahedi F, Shenouda MM, Lee AJ, Chew MV, Hogg RT, Lee DA, Ashkar AA.

J Immunother. 2017 Nov 17. doi: 10.1097/CJI.0000000000000192. [Epub ahead of print]

PMID:29189387

HIV research using the humanized mouse model demonstrates the importance of target cell number in the vaginal tract for infection is published in Scientific Reports:

Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice.

Nguyen PV, Wessels JM, Mueller K, Vahedi F, Anipindi V, Verschoor CP, Chew M, Deshiere A, Karniychuk U, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C.

Sci Rep. 2017 Nov 10;7(1):15263. doi: 10.1038/s41598-017-15630-z.

PMID:29127409

September 2017

 Sophie awarded Ontario Women's Health Scholars Award. Congratulations Sophie!

August 2017

 Leila and Elizabeth contriubute a chapter about the use of humanized mouse models for better understanding human-specific viruses in the Methods in Molecular Biology book series entitled Innate Antiviral Immunity: 

The Application of Humanized Mouse Models for the Study of Human Exclusive Viruses.

Vahedi F, Giles EC, Ashkar AA.

Methods Mol Biol. 2017;1656:1-56. doi: 10.1007/978-1-4939-7237-1_1.

PMID: 28808960

Our PhD student Amanda Lee successfully defends her PhD! Amanda has been an instrumental member of our laboratory and she will be greatly missed. All the best on your future endeavours Amanda!

July 2017

Mira's work demonstrating the effectiveness of primary NK cells against breast cancer patient-derived tumour cells was published in Breast Cancer Research:

Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.

Shenouda MM, Gillgrass A, Nham T, Hogg R, Lee AJ, Chew MV, Shafaei M, Aarts C, Lee DA, Hassell J, Bane A, Dhesy-Thind S, Ashkar AA.

Breast Cancer Res. 2017 Jul 1;19(1):76. doi: 10.1186/s13058-017-0867-9.

PMID:28668076

Tuberculosis research using the humanized mouse model is published in the Journal of Infectious Diseases:

Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.

J Infect Dis. 2017 Jul 1;216(1):135-145. doi: 10.1093/infdis/jix252.

PMID: 28531291

June 2017

Sophie awarded first place for her oral presentation on her Ovarian Cancer work at Oncology Research Day. Congratulations Sophie!

Amanda and Sophie present their work at this year's Perey Symposium.


Evan's work on cytokine stimulation of primary, ex vivo expanded NK cells is published in Molecular Immunology:

IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation.

Lusty E, Poznanski SM, Kwofie K, Mandur TS, Lee DA, Richards CD, Ashkar AA.

Mol Immunol. 2017 Aug; 88:138-147. doi 10.1093/infdis/jix252.

PMID: 28644973

Sophie's work on the effects of IL-18 and IL-12 on NK cells is published in the Journal of Innate Immunity:

Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells.

Poznanski SM, Lee AJ, Nham T, Lusty E, Larché MJ, Lee DA, Ashkar AA.

J Innate Immun. 2017;9(5):511-525. doi: 10.1159/000477172. Epub 2017 Jun 21.

PMID: 28633138
 May 2017

Sophie receives Excellence in Poster Presentation Award and MILO Best Commercial Potential Poster Award at the Faculty of Health Sciences Research Plenary. Congratulations Sophie!

March 2017

Amanda's work on elucidating the mechanism through which NK cells are activated during HSV-2 infection is published in Journal of Experimental Medicine:

Lee AJ, Chen B, Chew MV, Barra NG, Shenouda MM, Nham T, van Rooijen N, Jordana M, Mossman KL, Schreiber RD, Mack M, Ashkar AA.

J Exp Med. 2017 Apr 3;214(4):1153-1167. doi: 10.1084/jem.20160880. Epub 2017 Mar 6.

PMID: 28264883

February 2017

Yalda's work on endotoxin tolerance is published in Cytokine:

Type I interferon signalling is not required for the induction of endotoxin tolerance.

Karimi Y, Poznanski SM, Vahedi F, Chen B, Chew MV, Lee AJ, Ashkar AA.

Cytokine. 2017 Jul;95:7-11. doi: 10.1016/j.cyto.2017.01.017. Epub 2017 Feb 9.

PMID: 28189043