Humanized Mouse Model - An Experimental Model of Human Disease

Although mouse models have provided extremely valuable insights into basic physiology and pathology of human cells, tissues and organs, there are situations where they may not represent human defense/susceptibility against microbial pathogens and cancers. Studies of human cells, including human NK cells, and their interactions with human specific pathogens or cancer cells have largely been restricted to in vitro experiments and the lack of appropriate in vivo models has been a major impediment.  Recent advances in the generation of humanized mice have provided a valuable means of assessing the interaction of human cells with human pathogens or cancer cells in an in vivo setting.

We and others have developed this relevant pre-clinical humanized mouse model and our goal is to use this model to develop novel prevention and/or therapeutic strategies against human diseases.

Double Humanized Mouse Model for the Study of Hepatitis C Infection

Using FRG mice that have been reconstituted with human liver cells and autologous immune cells, we have generated an autologous double humanized mouse model. These mice have both a functional human immune system and human liver cells that can be infected wtih HCV to study HCV immunopathogenesis.