Publications

Ex vivo-expanded NK cells from blood and ascites of ovarian cancer patients are cytotoxic against autologous primary ovarian cancer cells.

Nham T, Poznanski SM, Fan IY, Shenouda MM, Chew MV, Lee AJ, Vahedi F, Karimi Y, Butcher M, Lee DA, Hirte H, Ashkar AA.

Cancer Immunol Immunother. 2018 Jan 3. doi: 10.1007/s00262-017-2112-x. [Epub ahead of print]

PMID: 29299659

High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women.

Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, Gibala MJ, Ashkar AA.

J Cancer Prev. 2017 Dec;22(4):260-266. doi: 10.15430/JCP2017.22.4.260. Epub 2017 Dec 30.

PMID: 29302585


Ex vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood are Cytotoxic Against Primary Breast Cancer Cells.

Nham T, Poznanski SM, Fan IY, Vahedi F, Shenouda MM, Lee AJ, Chew MV, Hogg RT, Lee DA, Ashkar AA.

J Immunother. 2017 Nov 17. doi: 10.1097/CJI.0000000000000192. [Epub ahead of print]

PMID:29189387


Ex Vivo Expanded Human NK cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.

Vahedi F, Nham T, Poznanski SM, Chew MV, Shenouda MM, Lee D, Ashkar AA.

Sci Rep. 2017 Sep 21;7(1): 12083. doi: 10.1038/s41598-017-12223-8.

PMID:28935883


The Application of Humanized Mouse Models for the Study of Human Exclusive Viruses.

Vahedi F, Giles EC, Ashkar AA.

Methods Molec Biol. 2017; 1656: 1-56. doi: 10.1007/978-1-4939-7237-1_1.

PMID:28808960 


Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.

Shenouda MM, Gillgrass A, Nham T, Hogg R, Lee AJ, Chew MV, Shafaei M, Aarts C, Lee DA, Hassell J, Bane A, Dhesy-Thind S, Ashkar AA.

Breast Cancer Res. 2017 Jul 1;19(1):76. doi: 10.1186/s13058-017-0867-9.

PMID:28668076


IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation.

Lusty E, Poznanski SM, Kwofie K, Mandur TS, Lee DA, Richards CD, Ashkar AA.

Mol Immunol. 2017 Aug;88:138-147. doi: 10.1016/j.molimm.2017.06.025. Epub 2017 Jun 20.

PMID: 28644973


Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells.

Poznanski SM, Lee AJ, Nham T, Lusty E, Larché MJ, Lee DA, Ashkar AA.

J Innate Immun. 2017 Jun 21. doi: 10.1159/000477172. [Epub ahead of print]

PMID: 28633138

A novel virus-vectored respiratory mucosal vaccine enhances anti-tuberculosis immunity in a humanized model system.

Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.

J Infect Dis. 2017 May 20. doi: 10.1093/infdis/jix252. [Epub ahead of print] 

PMID: 28531291


Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection. 

Lee AJ, Chen B, Chew MV, Barra NG, Shenouda MM, Nham T, Rooijen Nv, Jordana M, Mossman KL,

Schreiber RD, Mack M, Ashkar AA. J. Exp. Med. 2017 Mar 6;214(3). doi: 10.1084/jem.20160880. 

PMID: 28264883


Type I interferon signalling is not required for the induction of endotoxin tolerance.

Karimi Y, Poznanski S, Vahedi F, Chen B, Chew M, Lee A, Ashkar AA. Cytokine. 2017 Jul 31;95:7-11. 

doi: 10.1016/j.cyto.2017.01.017. 

PMID: 28189043


Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.

He W, Tan GS, Mullarkey CE, Lee AJ, Lam MM, Krammer F, Henry C, Wilson PC, Ashkar AA,

Palese P, Miller MS. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11931-11936.

doi:10.1073/pnas.1609316113. Epub 2016 Oct 3.

PMID: 27698132


M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.

Krneta T, Gillgrass A, Poznanski S, Chew M, Lee AJ, Kolb M, Ashkar AA. J Leukoc Biol.

doi:10.1189/jlb.3A1215-552R. Epub 2016 Aug 4. 

PMID: 27493241 


Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge

       Bulir D, Liang S, Lee A, Chong S, Simms E, Stone C, Kaushic C, Ashkar AA, Mahony J.

       Vaccine. 2016 Jul 25; 34(34): 3979-3985. doi: 10.1016/j.vaccine.2016.06.046. Epub 2016 Jun 17. 

       PMID: 27325352

 

Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice.

Dykstra C, Lee AJ, Lusty EJ, Shenouda MM, Shafai M, Vahedi F, Chew MV, Collins S, Ashkar AA.

BMC Immunol. 2016 Jun 16;17(1):18. doi: 10.1186/s12865-016-0157-9.

PMID: 27307066


S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria

C, Chen L, Rangwala Z, Hesch A, Chan ES, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas

G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y,

Lichty BD.

Nat Immunol. 2016 May;17(5):514-22. doi: 10.1038/ni.3433. Epub 2016 Apr 4.

PMID: 27043414


The breast tumor microenvironment alters the phenotype and function of natural killer cells.

Krneta T, Gillgrass A, Chew M, Ashkar AA. Cell Mol Immunol. 2015 Aug 17.

doi: 10.1038/cmi.2015.42. [Epub ahead of print]

PMID: 26277898


Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

Lauber S, Wong S, Cutz JC, Tanaka M, Barra N, Lhoták S, Ashkar A, Richards CD.

Int J Cancer. 2015 Feb 15;136(4):831-43. doi: 10.1002/ijc.29055. Epub 2014 Jul 7.

PMID: 24976180


Vitamin D3 modulates the function of chicken macrophages.

Shojadoost B, Behboudi S, Villanueva Al, Brisbin JT, Ashkar AA, Sharif S.

Res Vet Sci. 2015 Jun; 100: 45-51. doi:10.1016/j.rvsc.2015.03.009. Epub 2015 Mar 9.

PMID: 25814176


Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity.

Karimi K, Karimi Y, Chan J, Boudreau JE, Basset J, Chew MV, Reid S, Bramson JL, Wan Y,

Ashkar AA.

Innate Immun. 2015 Mar 5. pii:1753425915575078. [Epub ahead of print]

PMID: 25749844

 

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis and insulin resistance. 

Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard

A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley

KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG,

Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.

EMBO Mol Med. 2015 Feb 9. pii: e201404169. doi: 10.15252/emmm.201404169. [Epub ahead of print]

PMID: 25666722 


The absence or overexpression of IL-15 drastically alters breast cancer metastasis via effects on NK cells, CD4 T cells, and macrophages.

Gillgrass A, Gill N, Babian A, Ashkar AA.

J Immunol. 2014 Dec 15:193(12):6184-91. doi: 10.4049/jimmunol. 1303175. Epub 2014 Oct 29

PMID: 25355926 


Novel roles of cytoplasmic ICP0: proteasome-independent functions of the RING finger are required to block ISG production but not to promote viral replication. 

Taylor KE, Chew MV, Ashkar AA, Mossman KL.

J Virol. 2014 May 7.

PMID: 24807717


T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J,

Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL,

Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Apr 30. doi: 10.1038/mi.2014.29.

PMID: 24781052


Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection.

Lai R, Jeyanathan M, Shaler CR, Damjanovic D, Khera A, Horvath C, Ashkar AA, Xing Z.

Eur J Immunol. 2014 May;44(5):1375-86. doi: 10.1002/eji.201344300. Epub 2014 Apr 4.

PMID:24519467


HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF,

Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R,

Kaushic C.

J Immunol. 2013 Oct 15;191(8):4246-58. doi: 10.4049/jimmunol.1301482. Epub 2013 Sep 16.

PMID: 24043886


Type I interferon regulation of natural killer cell function in primary and secondary infections.

Stackaruk ML, Lee AJ, Ashkar AA.

Expert Rev Vaccines. 2013 Aug;12(8):875-84. doi: 10.1586/14760584.2013.814871. Review.

PMID: 23984959


Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type.

Mian MF, Ahmed AN, Rad M, Babaian A, Bowdish D, Ashkar AA.

J Leukoc Biol. 2013 Aug 2. [Epub ahead of print]

PMID: 23911868


Interleukin-15 is required for maximal lipopolysaccharide-induced abortion. 

Lee AJ, Kandiah N, Karimi K, Clark DA, Ashkar AA.

J Leukoc Biol. 2013 Jun;93(6):905-12. doi: 10.1189/jlb.0912442. Epub 2013 Mar 15.

PMID: 23505315


Immunity to ocular and genital herpes simplex viruses infections.

Chentoufi AA, BenMohamed L, Van De Perre P, Ashkar AA.

Clin Dev Immunol. 2012;2012:732546. doi: 10.1155/2012/732546. Epub 2012 Dec 26.                    

No abstract available.

PMID: 23326289


The influence of macrophages and the tumor microenvironment on natural killer cells.

Krneta T, Gillgrass A, Ashkar AA.

Curr Mol Med. 2013 Jan;13(1):68-79.

PMID: 22834841

PLoS One. 2012;7(6):e39553. doi: 10.1371/journal.pone.0039553. Epub 2012 Jun 29.

PMID: 22768089

Critical role of natural killer cells in lung immunopathology during influenza infection in mice.

Abdul-Careem MF, Mian MF, Yue G, Gillgrass A, Chenoweth MJ, Barra NG, Chew MV, Chan T,

Al-Garawi AA, Jordana M, Ashkar AA.

J Infect Dis. 2012 Jul 15;206(2):167-77. doi: 10.1093/infdis/jis340. Epub 2012 May 4.

PMID: 22561366

Genital HSV-2 infection induces short-term NK cell memory.

Abdul-Careem MF, Lee AJ, Pek EA, Gill N, Gillgrass AE, Chew MV, Reid S, Ashkar AA.

PLoS One. 2012;7(3):e32821. doi: 10.1371/journal.pone.0032821. Epub 2012 Mar 22.

PMID: 22457721

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.

Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD,  

Ma A, Ashkar AA.

J Immunol. 2012 May 1;188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23.

PLoS One. 2012;7(2):e31688. doi: 10.1371/journal.pone.0031688. Epub 2012 Feb 21.

PMID: 22363706

Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.

Karimi K, Solano ME, Ashkar AA, Ho H, Steidle EM, McVey Neufeld KA, Hecher K, Bienenstock

J, Arck PC.

J Mol Med (Berl). 2012 Sep;90(9):1047-57. doi: 10.1007/s00109-012-0872-5. Epub 2012 Feb 23.

Cancer Gene Ther. 2012 Apr;19(4):238-46. doi: 10.1038/cgt.2011.81. Epub 2011 Dec 9.

Curr Opin Infect Dis. 2012 Feb;25(1):92-9. doi: 10.1097/QCO.0b013e32834e9a56. Review.

PMID: 22143115

FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice.

Abdul-Careem MF, Firoz Mian M, Gillgrass AE, Chenoweth MJ, Barra NG, Chan T, Al-Garawi AA,

Chew MV, Yue G, van Roojen N, Xing Z, Ashkar AA.

Antiviral Res. 2011 Nov;92(2):346-55. doi: 10.1016/j.antiviral.2011.09.004. Epub 2011 Sep 14.

Diabetes Obes Metab. 2012 Feb;14(2):190-3. doi: 10.1111/j.1463-1326.2011.01495.x. Epub 2011

Oct 30.

J Infect Dis. 2011 Jul 15;204(2):299-308. doi: 10.1093/infdis/jir260.

PMID: 21673042

Humanized mice for Salmonella typhi infection: new tools for an old problem.

Mian MF, Pek EA, Chenoweth MJ, Coombes BK, Ashkar AA.

Virulence. 2011 May-Jun;2(3):248-52. Epub 2011 May 1.

Expert Rev Clin Immunol. 2011 May;7(3):367-82. doi: 10.1586/eci.10.102. Review.

Cell Immunol. 2011;269(1):29-37. doi: 10.1016/j.cellimm.2011.03.007. Epub 2011 Mar 12.

PMID: 21477795

A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection.

Thatte A, DeWitte-Orr SJ, Lichty B, Mossman KL, Ashkar AA.

Immunol Cell Biol. 2011 Aug;89(6):663-9. doi: 10.1038/icb.2011.7. Epub 2011 Feb 22.

J Reprod Immunol. 2011 Mar;88(2):210-8. doi: 10.1016/j.jri.2011.01.001. Epub 2011 Feb 21. Review.

PMID: 21334750

IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells.

Boudreau JE, Stephenson KB, Wang F, Ashkar AA, Mossman KL, Lenz LL, Rosenthal KL,

Bramson JL, Lichty BD, Wan Y.

Cancer Res. 2011 Apr 1;71(7):2497-506. doi: 10.1158/0008-5472.CAN-10-3025. Epub 2011 Feb 9.

PMID: 21307131

Induction of innate immune responses in the female genital tract: friend or foe of HIV-1 infection?

Firoz Mian M, Ashkar AA.

Am J Reprod Immunol. 2011 Mar;65(3):344-51. doi: 10.1111/j.1600-0897.2010.00945.x. Epub 2011

Jan 12. Review.

PMID: 21223417

Humanized mice are susceptible to Salmonella typhi infection.

Firoz Mian M, Pek EA, Chenoweth MJ, Ashkar AA.

Cell Mol Immunol. 2011 Jan;8(1):83-7. doi: 10.1038/cmi.2010.52. Epub 2010 Nov 8.

Cell Immunol. 2011;266(2):180-6. doi: 10.1016/j.cellimm.2010.10.002. Epub 2010 Oct 30.

Expert Rev Vaccines. 2010 Oct;9(10):1143-7. doi: 10.1586/erv.10.119.